I have been running a CellProfiler3.0 pipeline locally on my laptop for some time. For a typical 96-well plate (4 fields, 3 channels), it takes around 3-5 hours to run. We recently upgraded to 384-well plates in hopes of starting screening, and it’s taking well over 20 hours/plate. The program always indicates that it is running 4 workers, and I have done as much as I can to shorten the processing time (hiding all windows on run, reducing measurements collected, etc). I am wondering what would be the best way to improve processing time. We are open to getting a new desktop if necessary, or running on the cloud if that is feasible (my understanding of cloud computing is minimal). Thank you very much!